Ann N Y Acad Sci. 2004;1031:435-8.
Is all-rac-alpha-tocopherol different from RRR-alpha-tocopherol regarding
cardiovascular efficacy? A meta-analysis of clinical trials.
Kraemer K, Koch W, Hoppe PP.
BASF Aktiengesellschaft, Human Nutrition, Scientific & Regulatory Affairs,
ME/QR ? Li 725, Limburgerhof, 67117, Germany.
A meta-analysis of 14 clinical studies with RRR- or all-rac-alpha-tocopherol
(83,800 subjects) was performed to evaluate whether RRR and all-rac differ in
cardiovascular efficacy based on those clinical endpoints that are most
consistently documented in the publications of the studies. Odds ratios of
treatment versus control for individual studies and for studies pooled by form
were centered around unity, with no significant differences between vitamin E
forms. The results corroborate the present opinion that vitamin E supplements
up to 800 mg/d for up to 6.5 years are safe.